References:

1. https://www.telegraph.co.uk/science/2016/11/14/some-people-are-immune-to-alzheimers-symptoms-scientists-find/

2. https://news.northwestern.edu/stories/2016/11/elderly-discovered-with-superior-memory-and-alzheimers-pathology/

3. https://www.mdpi.com/1422-0067/22/9/4307

4. “Amyloid β (Aβ), the major component of senile plaques, is considered to play a central role in neuronal cell death”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430668/#:~:text=Amyloid%20%CE%B2%20(A%CE%B2)%2C%20the,role%20in%20neuronal%20cell%20death.

Yet activation of CaMKII has been shown to prevent cell death in the brain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276857/

5. https://www.brandeis.edu/now/2017/september/memory-molecule-CaMKII.html

6. This article talks about how a protein called FGF can create oligodendrocytes that rejuvenate your mind and restore memory.

https://english.elpais.com/science-tech/2022-05-12/memory-restoring-molecule-provides-new-hope-in-the-search-for-a-cure-for-alzheimers.html

However, new research now shows MaKII can create these oligodendrocytes, therefore producing the same end result. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685839/

7.https://www.baltimoresun.com/sdut-memory-malinow-ucsd-2014jun01-story.html

8. https://drive.google.com/file/d/1arjfptGnyUGAx--nBFSpFTgTD4uPJpse/view?usp=share_link

9. https://journals.physiology.org/doi/full/10.1152/jn.00485.2004

“oAβ Prevents the further cLTP- mediated activation of CaMKII”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089247/

10. https://drive.google.com/file/d/1v_4qBRqfdedisheaDuHZ9Lu1vTrdU_8-/view?usp=share_link

11. https://drive.google.com/file/d/1arjfptGnyUGAx--nBFSpFTgTD4uPJpse/view?usp=sharing

12. This meta study points to 3 studies on the memory molecule having been done on humans

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587077/

Another human study linking the memory molecule to episodic memory

https://www.pnas.org/doi/full/10.1073/pnas.0510212103

13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587077/

14. https://www.nature.com/articles/s41598-017-04355-8

15. https://www.frontiersin.org/articles/10.3389/fnmol.2018.00445/full

16. https://pubmed.ncbi.nlm.nih.gov/16079472/

17. https://www.sciencedirect.com/science/article/abs/pii/S0166432818310246

18. https://pubmed.ncbi.nlm.nih.gov/10656183/

19. https://www.mdpi.com/2072-6643/13/1/218#B13-nutrients-13-00218

20. https://www.mdpi.com/1424-8247/16/2/171

21. https://www.mdpi.com/2072-6643/13/1/218#B13-nutrients-13-00218

22. Results from numeric working memory accuracy test

Post dose change on day 1 = 0.35.

Post dose change on day 29 = 1.44.

The difference in the change over 29 days is 311.42%

23. Results from corsi blocks test

Placebo: -0.25

Sage: 0.25

The difference compared to placebo is a 196.296% increase.

https://drive.google.com/file/d/1UG-fx_1Vu1KgjblXhxW1E45Mb8DTU664/view?usp=share_link

24. Name-to-face recall test

Placebo: -6.75

Sage: -0.19

The difference compared to placebo is a 97.185% increase.

https://drive.google.com/file/d/1qpNyOTzKz1yixbU2O0KYA-N6WWN7vWAW/view?usp=share_link

25. Speed of memory test – after 6 hours of taking sage oil

Placebo: 18.59 milliseconds faster compared to baseline

Treatment: -138.7 milliseconds faster compared to baseline

That means the treatment group was 646.1% faster compared to placebo.

26. Speed of attention test – after 1 hours of taking sage oil

25 ul group: 0.16 milliseconds faster compared to baseline

50 ul group: 3.40 milliseconds faster compared to baseline

That means the 50 ul group was 2,025% faster compared to the 25 ul group.

27. https://tulsimandir.com/the-sacred-tulsi

28. https://molpharm.aspetjournals.org/content/molpharm/early/2005/12/19/mol.105.018853.full.pdf

29. https://www.ijpp.com/IJPP%20archives/2015_59_1/69-77.pdf

30. Results from Sternberg memory test after supplementation

Baseline: 4.68

Day 30: 1.60

That equates to a 192.5% increase in short-term memory performance

31. Results from interference task

Baseline: 4.05

Day 30: 1.34

That equates to a 202% increase in mental accuracy

32. Result from reaction time on stroop test

Placebo improved by 35.7 by day 30

Treatment group improved by 110.7 by day 30

That means the treatment group had a 210% (or 3x) increase in reaction speed compared to control.

33. https://pubmed.ncbi.nlm.nih.gov/26571987/

34. https://www.webmd.com/vitamins/ai/ingredientmono-761/bacopa

35. “We here report that ACh induces Ca2+ influx via T-type Ca2+ channel by activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII)”

https://www.sciencedirect.com/science/article/abs/pii/S0006291X07013277

36. https://www.researchgate.net/publication/346626988_Standardized_

Extract_Ameliorates_Learning_and_Memory_Impairments_through_Synaptic_Protein_Neurogranin_Pro-and_Mature_BDNF_Signaling_and_HPA_Axis_in_Prenatally_Stressed_Rat_Ospring Measuring reaction time of attention for 300mg treatment group Baseline: 2287.32 12 weeksL 1921.24 That equals a 16% increase. 

37. https://www.hindawi.com/journals/ecam/2012/606424/

38. Measuring continuity of attention (ability to stay focused) for the 300mg treatment group.

Baseline: 116.35

12-weeks 154.81

That equals a 33% increase.

39. http://thishel.ps/PDF_Studies/1125.pdf

40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1123448/#__ffn_sectitle

41. https://academic.oup.com/ajcn/article-abstract/9/3/324/4829480?redirectedFrom=fulltext

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